Ambien (zolpidem) and alcohol should not be combined. Both depress the central nervous system, and together they can cause extreme drowsiness, dizziness, impaired coordination, memory loss, and slowed or difficult breathing. This combination raises the risk of accidents, overdose, and dangerous behaviors like sleepwalking or sleep-driving. In severe cases, it can be life-threatening. Always avoid alcohol when taking Ambien and follow your doctor’s guidance carefully.