Yes, tramadol can cause seizures in humans. It lowers the seizure threshold, meaning seizures can occur even at therapeutic doses, though the risk increases with high doses, misuse, or combining it with other drugs like antidepressants, antipsychotics, or alcohol. People with a history of seizures are at higher risk. Because of this, tramadol should be used cautiously and only as prescribed, with careful attention to drug interactions and dosing limits.