If you take Lunesta eszopiclone hypnotic medication and Xanax alprazolam benzodiazepine together, their sedative effects can strongly add up, causing extreme drowsiness, confusion, poor coordination, memory impairment, and slowed breathing. In severe cases, it can lead to unconsciousness, overdose, or life-threatening respiratory depression, especially with alcohol or other depressants. This combination should only be used under strict medical supervision. Seek emergency help if breathing slows significantly or unresponsiveness occurs immediately.