Gabapentin and Oxycodone differ mainly in use and risk. Gabapentin treats nerve pain and seizures, acting on calcium channels, with lower addiction risk. Oxycodone treats moderate–severe pain by binding opioid receptors, carrying high risks of dependence, tolerance, and respiratory depression. Gabapentin causes dizziness and fatigue; oxycodone commonly causes sedation, constipation, and potential overdose, requiring stricter medical supervision and caution.