Mixing Ibuprofen with alcohol is not recommended. Both can irritate the stomach lining, increasing the risk of gastritis, ulcers, and gastrointestinal bleeding. Alcohol may also worsen dizziness or drowsiness in some people. Occasional small amounts might not cause harm in healthy individuals, but regular or heavy drinking significantly raises risks. It’s safest to avoid alcohol while taking ibuprofen, especially at higher doses or for long-term use.