Pain is a common healthcare concern that can affect a person's mobility, sleep, productivity, and quality of life. Depending on the cause and severity of pain, healthcare professionals may recommend different approaches, including physical therapy, non-opioid medicines, behavioral strategies, and, in selected circumstances, opioid medications. Vicodin is a brand historically associated with a combination of hydrocodone and acetaminophen, two medicines that work through different mechanisms to provide pain relief.