Oxycodone is a prescription opioid medication used for certain types of pain when a healthcare professional determines that an opioid analgesic is appropriate. Searches such as “Order Oxycodone Online No Rx Expedited Overnight Domestic Delivery” may appear in online pharmacy results, but consumers should understand that legitimate pharmacies require an appropriate prescription before dispensing Oxycodone. FDA guidance identifies websites that offer prescription medicines without requiring a prescription as a major warning sign.