To date, there are few literature reports that summarize PROTAC metabolism studies. Therefore, in this article, we share some examples of DMPK studies of PROTAC with the experience of the Medicilon DMPK department and hope to be helpful to all researchers who are interested in PROTAC molecular DMPK. The Medicilon PROTAC drug discovery technology platform includes: (1)The design of synthetic PROTAC-POI (2)In vitro screening of PROTAC-POI (3)The in vivo efficacy and PK/PD studies (4)Pharmacological analysis (5)Pharmacokinetic studies (6)Safety evaluation of PROTAC-POI, (7) The aggregation of experimental results and materials for IND filing to help customers accelerate the development of PROTAC-POI drugs. https://www.medicilon.com/services/drug-safety-evaluation/ https://www.medicilon.com/platform/protac-drug-discovery-research-platform/