MindRank's GLP-1RA small molecule oral drug has been successfully administered to the first subject in clinical phase I. Medicilon as a strategic partner of MindRank, provided MDR-001 with API process development and preparation R&D services to help speed up its research and development.

On June 16, 2023, the "2023 Chinese Pharmaceutical CRO Enterprise Ranking" was released. Shanghai Medicilon Inc. was once again shortlisted for the 2023 China Pharmaceutical CRO Enterprise Ranking List.

Recently, the IND application of TollB-001 Tablets, a class 1.1 new drug for rheumatoid arthritis by Toll Biotech, has been officially approved by the FDA. Medicilon provided pharmaceutical research services, including raw materials and preparation, for TollB-001 tablets, which accelerated the research process.

Shanghai Medicilon Inc. (Medicilon) was awarded the "2023 Growth Potential Company" by virtue of its stable and excellent profitability, innovation ability, and competitive strength.

Recently, Medicilon and DP Technology Ltd. announced the signing of a strategic collaboration agreement. The two parties will work together to build an integrated AI platform for early drug discovery and evaluation based on AI4S.

Recently, Raymon Pharma announced that the clinical trial of self-developed RA1115-B1 eye drops for the treatment of neovascular (wet) age-related macular degeneration (wAMD) was launched in China. Medicilon provided pharmaceutical research services such as raw material drug production, raw material drug process development, and preparation prescription process development to accelerate the R&D process.

Shanghai Medicilon Inc. (Medicilon) has the honor to interview Dr. Fei Zhang, the founder of Raymon Pharma, to share his unique insights in the field of ophthalmic drugs.

In the formulation of GLP-1 integrated research plan, Medicilon has in-depth communication with customers. Medicilon provides GLP-1 drug discovery, CMC research (API + formulation), pharmacodynamics research, PK study, GLP-1 safety evaluation and other services.https://www.medicilon.com/platform/drug-discovery/

Jingxin awarded the Medicilon DMPK team and the New Drug Registration Department "Outstanding Contribution Team Award" and a letter of thanks.

Recently, the "3rd Pharmaceutical Innovation Award", a major award that has attracted the attention of pharmaceutical industry experts, academia, and the capital market, was released. Medicilon was honored again the "Top Ten Drug Innovation Service Institutions of the Year". It once again demonstrates the industry's high recognition of Medicilon's technical strength, service capabilities and development potential. The "Pharmaceutical Innovation Award" is organized by the Securities Times, aiming to promote the improvement of drug innovation capabilities by selecting outstanding drug innovation projects, outstanding companies and outstanding figures in China. The selection expert committee conducts selection based on the "Finance - Innovative Drug Index" database, drug evaluation and other related factors. The event attracted more than 100 pharmaceutical companies, innovative drug R&D companies, and medical service companies to particip

Safety pharmacology (safety pharmacology) research is an important part of the non-clinical safety evaluation of new drugs when the dose of the main research drug is within the therapeutic range or above the therapeutic range. There are potential undesired adverse effects. And observed in the study / or speculated adverse drug reaction mechanism so as to maximize the protection of new drugs before entering clinical research or after marketing early detection of possible adverse reactions beyond the therapeutic effect. When some adverse reactions to humans and animals are observed or speculated in other non-clinical trials and clinical trials, safety pharmacology research should be added and supplemented. The objectives of safety pharmacology research include: ① determine the undesired pharmacological effects of drugs that may be related to human safety; ② evaluate the adverse drug reactions and (or) pathophysiology of drugs observed in toxicology and (or) clinical research ③ observe

Cell & gene therapy has developed by leaps and bounds in recent years, providing the possibility for many refractory diseases. With the rapid development of gene transduction and modification technology, delivery vector system, cell culture technology and other technology, breakthroughs have been made in cell & gene therapy, providing a new treatment concept and train of thoughts. Medicilon's preclinical research services cover pharmacodynamic research, drug safety evaluation, pharmacokinetic research, bioanalysis, etc. The establishment of a complete gene therapy R&D platform can provide one-stop services for research on pharmacological efficacy, biodistribution and safety evaluation of cell and gene therapy products. Medicilon has established a one-stop research platform for the preclinical research and development of cellular immunotherapy drugs, covering a variety of immunotherapy methods including CAR-T, TCR-T, CAR-NK and TIL cells, etc. Using a wealth of animal

General Pharmacology research refers to the study of extensive pharmacological effects of new drugs other than the main pharmacological effects. It mainly studies the effects of drugs on the spirit, nervous system, cardiovascular system, respiratory system, and other systems. General Pharmacology Research of New Drugs is divided into three categories, namely Primary Pharmacodynamic, Secondary Pharmacodynamic and Safety Pharmacology. In addition, additional and/or supplementary studies on safety pharmacology (Follow-up and Supplemental Safety Pharmacology Studies) may be required according to experimental requirements. Safety pharmacology is mainly to study the potential undesired adverse effects on physiological functions of drugs at doses within or above the therapeutic range, that is, to observe the effects of drugs on the central nervous system, cardiovascular system, and respiratory system. Additional and/or supplementary safety pharmacology studies may be conducted as needed.ht

Many impurities in drugs can produce toxic and side effects, which is a crucial factor affecting the safety and effectiveness of drugs, especially genotoxic impurities that can cause serious harm to human health with minimal exposure. Therefore, to ensure API quality and preparations, Genotoxic impurities are a class of impurities that must be paid attention to in the drug synthesis process. Genotoxic impurities from chemical reagents, chemical synthesis, and reaction are involved in all aspects of the drug synthesis process and the subsequent stability and possible degradation of the drug, which is a complex process. For potential carcinogenic or mutagenic substances and impurities with warning structures, the Ames test can generally be used to test the mutagenic ability of impurities.https://www.medicilon.com/services/drug-safety-evaluation/

To date, there are few literature reports that summarize PROTAC metabolism studies. Therefore, in this article, we share some examples of DMPK studies of PROTAC with the experience of the Medicilon DMPK department and hope to be helpful to all researchers who are interested in PROTAC molecular DMPK. The Medicilon PROTAC drug discovery technology platform includes: (1)The design of synthetic PROTAC-POI (2)In vitro screening of PROTAC-POI (3)The in vivo efficacy and PK/PD studies (4)Pharmacological analysis (5)Pharmacokinetic studies (6)Safety evaluation of PROTAC-POI, (7) The aggregation of experimental results and materials for IND filing to help customers accelerate the development of PROTAC-POI drugs. https://www.medicilon.com/services/drug-safety-evaluation/ https://www.medicilon.com/platform/protac-drug-discovery-research-platform/

(1) Pre-clinical research content 1. Literature research includes drug name and naming basis, the purpose and basis of the topic. 2. Pharmacy research. Raw material technology research, formulation prescription and technology research, confirmation of chemical structure or component test, drug quality test, drug standard drafting and description, sample inspection, auxiliary materials, stability test, packaging material and container related test, etc. 3. Pharmacology and Toxicology Research. General pharmacology tests, main pharmacodynamic tests, acute toxicity tests, long-term toxicity tests, allergic, hemolytic and local irritation tests, mutagenicity tests, reproductive toxicity tests, carcinogenic toxicity tests, dependence tests, animals Pharmacokinetic tests, etc. https://www.medicilon.com/services/drug-safety-evaluation/

Recently, Ringene Biopharma, an innovative drug R&D company focusing on the development of drugs targeting RTK-RAS-MAPK signaling pathway, independently developed a new class of anti-tumor drugs, the irreversible pan-FGFR inhibitor RG002, which was approved clinical. The indications are advanced malignant tumors.In the R&D of RG002, Shanghai Medicilon Inc. provides drug discovery sevices in the form of FTE collaboration to clinical application, including preclinical research, drug discovery, pharmaceutical research and preclinical research (pharmacy, safety assessment), which accelerated the research process of RG002.https://www.medicilon.com/services/drug-safety-evaluation/

Cardiac safety evaluation is an important factor that must be investigated before various new drugs enter clinical trials, and it is also one of the most important and difficult links in the early clinical research of innovative drugs. The QT interval of the heart refers to the period from the beginning of the QRS complex to the end of the T wave, including the process of ventricular depolarization and repolarization. The QT interval is considered to be one of the key indicators for the safety evaluation of new drugs. In cardiomyocytes, the potassium channel encoded by hERG (human Ether-a-go-go Related Gene) mediates a delayed rectifier potassium current (IKr), and IKr inhibition is an important mechanism by which drugs lead to prolongation of the QT interval. hERG can be inhibited by compounds with diversified structures. The loss of its function or drug inhibition will affect the repolarization process of cardiac action potentials and cause the QT interval to prolong. At the same tim

On January 31, Medicilon, the team of Dr. Chen Ling of the State Key Laboratory of Respiratory Diseases (SKLRD) and Guangzhou nBioMed have reached a scientific research collaboration agreement. The three parties will establish a strategic collaborative partnership to integrate the advantages and strength of all parties to develop the new coronavirus vaccine. https://www.medicilon.com/services/drug-safety-evaluation/

Drug Safety Evaluation Center The drug safety evaluation package research data provided by Medicilon puya was reported to CFDA, the US FDA, and the Australian TGA 15 times for Investigational New Drug (IND for short). , Australia TGA declared Investigational New Drug (IND) more than 60 times. https://www.medicilon.com/services/drug-safety-evaluation/

Medicine is a double-edged sword. It can cure diseases, save people, and produce adverse reactions that damage human health. Reproductive toxicity studies are one of the essential contents of drug toxicity research, which refers to the damage of drugs to reproductive function and ability and the unfavorable mailbox for offspring. For drugs to be used in humans, animal reproductive toxicity tests need to be comprehensively considered based on the intended indications and characteristics of the test substance.

Medicilon has a professional team and practical experience in drug safety evaluation, which can provide high-quality data and a fast turnaround period to support various drug safety evaluation studies. Toxicological studies can be performed in accordance with non-GLP or GLP standards. Our research platform has been rated as Shanghai R&D Public Service Platform. Medicilon Drug Safety Evaluation Service Project (1) Single and multiple dose toxicity test (rodent) (2) Single and multiple dose toxicity tests (non-rodent) (3) Reproductive toxicity test (Section I, Section II, Section III) (4) Genotoxicity test (Ames, micronucleus, chromosome aberration) (5) Carcinogenicity test (6) Local toxicity test (7) Immunogenicity test (8) Safety pharmacological test (9) Toxicokinetic test https://www.medicilon.com/press-events/shanghai-drug-safety-evaluation-center/

Patient-Derived Tumor Xenograft Model (PDX) is widely used in the development of new drugs, especially in the selection of patients in clinical trials of target drugs and the study of predictive biomarkers.Animal models such as genome-edited mouse models, patient-derived organoids, and patient-derived xenografts (PDX) have been used to study cancer biology and cancer pathogenesis studies.Medicilon’s research on PDX model includes molecular level genotyping and pharmacological efficacy evaluation service of orthotopic model, promising great prediction for clinical efficacy research.

The reproductive toxicity test divides into sections I, section II, and section III reproductive toxicity test. Part I reproductive toxicity test: also known as general reproductive toxicity test. The drug administers before the animal mating, and the purpose is to evaluate whether the germ cells have any adverse effects on the conception ability, the reproductive system, and the offspring after receiving the drug. Part II Reproductive Toxicity Test: Teratogenic susceptibility period toxicity test. Administration during the organogenesis period aims to reveal the possible embryotoxicity and teratogenicity of the drug. Part Ⅲ Reproductive toxicity test: also known as perinatal toxicity test. During the perinatal period and lactation period, the drug administers to observe the drug's effect on the growth and development of the fetus after birth. https://www.medicilon.com/services/pharma-toxicology/

Medicilon provides comprehensive chemistry research services covering all stages of your project requirements, and customers can cooperate with us through the FFS (Fee for Service) or FTE (Full-time Equivalent Service) models.

Recently, Pfizer's new crown-specific drug Paxlovid and the national miracle drug Ibuprofen are the most popular drugs in the medical circle. Today we will talk about the synthesis and mechanism of action of Ibuprofen, an evergreen drug! Recently, Ibuprofen has been hard to find, and it has become a well-known hard currency. Medicilon’s Synthetic Chemistry Services：https://www.medicilon.com/services/synthetic-chemistry/ Medicilon can undertake the synthesis of special reagents, intermediates and molecular fragments, preparation of standard products, synthesis design and preparation of impurities or metabolites, synthesis of stable isotope internal standards and synthesis of tritiated compounds.

Medicilon has a professional team and practical experience in drug safety evaluation, and can provide high-quality data and fast turnaround to support various drug safety evaluation studies. Toxicology studies can be performed in accordance with non-GLP or GLP standards. Our research platform has been rated as the Shanghai R&D public service platform. Medicilon drug safety evaluation service: https://www.medicilon.com/services/drug-safety-evaluation/ Single and multiple dose toxicity test (rodent) Single and multiple dose toxicity test (non-rodent) Reproductive toxicity test (section I, section II, section III) Genotoxicity test (Ames, micronucleus, chromosome aberration) Carcinogenicity test Local toxicity test Immunogenicity test Safety pharmacological test Toxicokinetic test

October 29th, 2022, is the seventeenth “World Stroke Day.” “World Stroke Day” was established by the World Stroke Organization (World Stroke Organization) to call for strengthening public awareness of stroke globally. Stroke is the scientific name of cerebralvascular accident, which generally refers to ischemic or hemorrhagic diseases of the heart, brain and tissues of the whole province caused by hyperlipidemia, blood clotting, atherosclerosis, hypertension, etc. It is a sudden onset of cerebral blood circulation disorders. The clinical manifestations are mainly characterized by sudden dizziness, unconsciousness, or sudden deviated eyes, hemiplegia, and intellectual disability. Stroke mainly includes ischemic stroke (transient ischemic attack, atherosclerotic thrombotic cerebral infarction, lacunar cerebral infarction, cerebral embolism) and hemorrhagic stroke (cerebral hemorrhage, subarachnoid hemorrhage). Stroke is known as “the number one killer of human health” because of it