https://nuheals.com/oxycontin-vs-hydrocodone/ The formulation, potency, and duration of action of two potent opioids that are frequently prescribed for the treatment of moderate to severe pain are OxyContin and Hydrocodone. For people with chronic pain who need constant pain management throughout the day, OxyContin, a brand name for oxycodone, is perfect because it is made for extended-release, offering comfort that lasts for a maximum of twelve hours. Hydrocodone, on the other hand, is normally prescribed for short-term pain treatment and is frequently paired with acetaminophen or ibuprofen. It has a faster onset of action but a shorter duration, usually 4 to 6 hours. Both drugs have the potential to cause dependence and adverse effects, however certain individuals may have more severe side effects due to OxyContin's greater strength.