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Altering the local structure of the peptide, although introducing some degree of conformational bias, produces minimal modifications to the original peptide. Such modifications are generally limited to single amino acids and can be divided into local modifications to the backbone and side chains. Changes in single amino acids have been reported to cause extensive changes in peptide structure, such as substitution of carbonyl groups with thiol, methylene, phosphinic and boronic acid groups. The use of unnatural amino acids as building blocks for the development of peptidomimetics has now attracted extensive research interest. Local modifications of peptidomimetics can include α-amino acids bearing modified side chains, rigid cyclic compounds that are isosteres of amino acids, and so on.
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Cocoa color is a natural food color. The pigment is extracted from the outer shell of the cocoa tree fruit of the sycamore family. Cocoa pigment is easily soluble in water, has good stability to light, heat and oxidant, and has strong coloring ability. Its color deepens with the increase of pH value, but has little effect on its hue. Cocoa pigment has good coloring ability for protein and starch, and seldom modifications throughout processing and preservation.
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Telomeres shorten with age, but also due to the environment, poor eating habits, smoking, lack of exercise and other bad behavioral habits. When these factors occur, they can lead to premature telomere shortening causing aging and even serious disease. Although there is much research on telomeres, there is still a need for us to continue to explore more mechanisms of telomere influence to help us avoid accelerated telomere shortening as well as to use positive influences to slow telomere attrition.
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