Technology

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Ad fiber knob CD40 scFv IgG: Recombinant Anti-Ad fiber knob x Anti-CD40 Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-Ad fiber knob antibody variable domain are respectively connected to the N terminus of the anti-CD40 IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Recombinant Anti-Ad fiber knob x Anti-CD40 Bispecific Antibody (scIgG) is designed to be expressed as two chains, each chain has the same units with their parental IgG antibodies, anti-Ad fiber knob and anti-CD40 IgGs. The two chains form heterodimer via Fc KIH technology. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

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In several cancer immunotherapies, tumor-infiltrating immune cells have been seen as promising markers for revealing the immune responses and tumor control. For examining the diversity of cells and chemicals in the tumor microenvironment (TME), scOmics methods are frequently used. In the meanwhile, scOmics study of immune cells that infiltrate tumors is essential to understanding cell interactions in cancer research. For quantifying several cell types, including T cells, B cells, dendritic cells (DCs), natural killer cells (NKs), macrophages, myeloid-derived suppressor cells (MDSCs), and neutrophils, Single Cell now offers a variety of single-cell omics services.

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