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Hydrocodone and codeine are both opioids used to manage pain, but they differ in potency, side effects, and medical applications. Hydrocodone is stronger and typically prescribed for moderate to severe pain, often combined with other medications like acetaminophen. Codeine is milder, usually prescribed for mild to moderate pain or as a cough suppressant. Both carry risks of addiction, drowsiness, and constipation, but hydrocodone has a higher potential for misuse due to its potency.