Technology

Cardiac safety evaluation is an important factor that must be investigated before various new drugs enter clinical trials, and it is also one of the most important and difficult links in the early clinical research of innovative drugs. The QT interval of the heart refers to the period from the beginning of the QRS complex to the end of the T wave, including the process of ventricular depolarization and repolarization. The QT interval is considered to be one of the key indicators for the safety evaluation of new drugs. In cardiomyocytes, the potassium channel encoded by hERG (human Ether-a-go-go Related Gene) mediates a delayed rectifier potassium current (IKr), and IKr inhibition is an important mechanism by which drugs lead to prolongation of the QT interval. hERG can be inhibited by compounds with diversified structures. The loss of its function or drug inhibition will affect the repolarization process of cardiac action potentials and cause the QT interval to prolong. At the same tim

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To date, there are few literature reports that summarize PROTAC metabolism studies. Therefore, in this article, we share some examples of DMPK studies of PROTAC with the experience of the Medicilon DMPK department and hope to be helpful to all researchers who are interested in PROTAC molecular DMPK. The Medicilon PROTAC drug discovery technology platform includes: (1)The design of synthetic PROTAC-POI (2)In vitro screening of PROTAC-POI (3)The in vivo efficacy and PK/PD studies (4)Pharmacological analysis (5)Pharmacokinetic studies (6)Safety evaluation of PROTAC-POI, (7) The aggregation of experimental results and materials for IND filing to help customers accelerate the development of PROTAC-POI drugs. https://www.medicilon.com/services/drug-safety-evaluation/ https://www.medicilon.com/platform/protac-drug-discovery-research-platform/

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Increasing scrutiny and regulatory complexity is a key factor driving market revenue growth Market Size – USD 9.70 Billion in 2022, Market Growth – at a CAGR of 25.9%, Market Trends – Increasing investments in advanced technologies in North America

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In the formulation of GLP-1 integrated research plan, Medicilon has in-depth communication with customers. Medicilon provides GLP-1 drug discovery, CMC research (API + formulation), pharmacodynamics research, PK study, GLP-1 safety evaluation and other services.https://www.medicilon.com/platform/drug-discovery/

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