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Cyclophosphamide, also known as cytophosphane, appears as a white to almost white crystalline powder with a slightly bitter taste. The chemical name of it is p-[N,N-bis-(2-chloroethyl)]-1-oxo-3-nitrogen-2-phosphocyclohexane-p-oxide monohydrate. Cyclophosphamide is a synthetic alkylating agent chemically related to nitrogen mustard with antineoplastic and immunosuppressive activities, which was approved for medical use in the United States in 1959. The structure is shown in fig. 1.
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Fig. 1 Structure of cyclophosphamide
Application in the treatment of cancer and autoimmune diseases
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