Technology

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In many cases, gene therapy requires a vector to deliver the gene therapy drug to the target cell. Viral vectors have been one of the most widely studied vectors due to their outstanding transduction efficiency and other significant advantages. Viral vector-based gene therapy has now achieved good clinical results. More than a dozen viral gene therapy products have been approved for the treatment of cancer, infectious diseases, and rare single-gene disorders. The main types of viral vectors used clinically for in vivo gene therapy include adenovirus, adeno-associated virus (AAV), herpes simplex virus (HSV), retroviruses, and lentiviruses. In recent years, scientific advances in viral vector engineering, rare disease genome identification, and gene editing are ushering in a new era of viral gene therapy. Rare disease research institutions are committed to using cutting-edge technologies in molecular biology and cell biology to provide comprehensive viral vector development solutions,

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Proteins are complex molecular entities with different sizes, molecular structures, and physical and chemical properties. Protein characterization is one of the important parts of protein expression. Characterizing a protein can obtain useful information on its identity, purity, structure, conformation, and activity. The precise molecular weight, amino acid sequence, charge variances, aggregation level, glycosylation, and oxidation level are the key to the in-depth characterization of proteins. Different post-translational modifications, highly specific three-dimensional structures, and the potential for aggregation, adsorption, and truncation determine the complexity of proteins. No one analytical platform or technique can meet all the requirements to characterize proteins so far.

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